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Carbohydr Polym. 2018 Feb 1;181:368-375. doi: 10.1016/j.carbpol.2017.10.083. Epub 2017 Oct 27.

Protective effects of natural and partially degraded konjac glucomannan on Bifidobacteria against antibiotic damage.

Author information

1
State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, PR China; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
2
State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, PR China; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. Electronic address: zhongping.yao@polyu.edu.hk.
3
State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, PR China; Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. Electronic address: jian-yong.wu@polyu.edu.hk.

Abstract

This study was to evaluate the protective effects of a dietary fiber, konjac glucomannan (KGM) from the plant tuber of Amorphohallus konjac on Bifidobacteria against antibiotic damage. KGM (∼8.8×108Da) was partially degraded with high-intensity ultrasound to KGM-US (∼1.8×106Da) and then hydrolyzed with trifluoroacetic acid (TFA) to KGM-AH (1369Da). KGM-US (at 5g/l) showed the most significant protective effect on most bifidobacterial strains against penicillin and streptomycin inhibition, increasing the minimal inhibitory and bactericidal concentration (MIC and MBC) dramatically, and KGM also showed significant effects on enhancing the MBC of enrofloxacin, penicillin, tetracycline and streptomycin. In addition, the adsorbance ability and biofilm formation effects of KGM and degraded KGM products may be partially responsible for the protective effects. The results suggested that natural KGM and ultrasound treated KGM have protective effects for the human gut probiotic bacteria against the damage caused by specific antibiotics.

KEYWORDS:

Antibiotics; Bifidobacteria; Konjac glucomannan; Partial degradation; Prebiotic fiber

PMID:
29253985
DOI:
10.1016/j.carbpol.2017.10.083
[Indexed for MEDLINE]

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