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Behav Brain Res. 2018 Apr 2;341:45-49. doi: 10.1016/j.bbr.2017.12.019. Epub 2017 Dec 15.

Recombinant growth differentiation factor 11 influences short-term memory and enhances Sox2 expression in middle-aged mice.

Author information

1
Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6 Canada. Electronic address: min.zhang@carleton.ca.
2
Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6 Canada. Electronic address: nafisa.jadavji@mail.mcgill.ca.
3
Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6 Canada. Electronic address: HyungYoo@cunet.carleton.ca.
4
Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6 Canada. Electronic address: patrice.smith@carleton.ca.

Abstract

Previous evidence suggests that a significant decline in cognitive ability begins during middle-age and continues to deteriorate with increase in age. Recent work has demonstrated the potential rejuvenation impact of growth differentiation factor-11 (GDF-11) in aged mice. We carried out experiments to evaluate the impact of a single dose of recombinant (rGDF-11) on short-term visual and spatial memory in middle-aged male mice. On the novel object recognition task, we observed middle-aged mice treated rGDF-11 showed improved performance on the novel object recognition task. However, middle-aged mice did not show increased expression of phosphorylated-Smad2/3, a downstream effector of GDF-11. We noted however that the expression of the transcription factor, Sox2 was increased within the dentate gyrus. Our data suggest that a single injection of rGDF-11 contributes to improvements in cognitive function of middle-aged animals, which may be critical in the preservation of short-term memory capacity in old age.

KEYWORDS:

Cognitive decline; GDF-11; Short term memory; Sox2

PMID:
29253511
DOI:
10.1016/j.bbr.2017.12.019
[Indexed for MEDLINE]

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