Format

Send to

Choose Destination
Bioessays. 2018 Feb;40(2). doi: 10.1002/bies.201700148. Epub 2017 Dec 18.

Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.

Author information

1
UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT, UK.
2
Barcelona Supercomputing Center (BSC), C/ Jordi Girona 39-31, 08034, Barcelona, Spain.
3
ICREA, Pg. Lluís Companys 23, 08010, Barcelona, Spain.
4
MRC/BHF Cardiovascular Epidemiology Unit Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
5
Department of Human Genetics Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1HH, UK.

Abstract

Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and inter-individual level, provides great opportunity for disease prevention, better therapeutic approaches, and personalized medicine.

KEYWORDS:

3D chromatin structure; DNA methylation; biological noise; chromatin; epigenetics; gene expression; genome architecture; heterogeneity; transcription; variability

PMID:
29251357
DOI:
10.1002/bies.201700148

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center