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Eur J Neurosci. 2018 Oct;48(7):2482-2497. doi: 10.1111/ejn.13807. Epub 2018 Jan 24.

Temporal coupling of field potentials and action potentials in the neocortex.

Author information

1
Department of Psychiatry, University of Michigan, BSRB 109 Zina Pitcher Place, Ann Arbor, 48109, MI, USA.
2
The Neuroscience Institute, School of Medicine, New York University, New York, NY, USA.
3
Center for Neural Science, School of Medicine, New York University, New York, NY, USA.

Abstract

The local field potential (LFP) is an aggregate measure of group neuronal activity and is often correlated with the action potentials of single neurons. In recent years, investigators have found that action potential firing rates increase during elevations in power high-frequency band oscillations (50-200 Hz range). However, action potentials also contribute to the LFP signal itself, making the spike-LFP relationship complex. Here, we examine the relationship between spike rates and LFP in varying frequency bands in rat neocortical recordings. We find that 50-180 Hz oscillations correlate most consistently with high firing rates, but that other LFP bands also carry information relating to spiking, including in some cases anti-correlations. Relatedly, we find that spiking itself and electromyographic activity contribute to LFP power in these bands. The relationship between spike rates and LFP power varies between brain states and between individual cells. Finally, we create an improved oscillation-based predictor of action potential activity by specifically utilizing information from across the entire recorded frequency spectrum of LFP. The findings illustrate both caveats and improvements to be taken into account in attempts to infer spiking activity from LFP.

KEYWORDS:

action potential; cortex; local field potential

PMID:
29250852
PMCID:
PMC6005737
[Available on 2019-04-01]
DOI:
10.1111/ejn.13807

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