Single nucleotide polymorphism rs1800872 in the promoter region of the IL10 gene is associated with predisposition to chronic hepatitis C in Russian population

Microbes Infect. 2018 Mar;20(3):212-216. doi: 10.1016/j.micinf.2017.11.012. Epub 2017 Dec 14.

Abstract

Previously, we studied an association of two IL28B gene single nucleotide polymorphisms (SNPs) and three IL10 gene SNPs with predisposition to tick-borne encephalitis in a Russian population. In this study, a possible involvement of these SNPs in the development of predisposition to chronic hepatitis C (caused by structurally similar, related virus from the Flaviviridae family) was investigated in the same population. Only the IL10 promoter rs1800872 SNP was associated with predisposition to chronic hepatitis C. This SNP seems to be a common genetic marker of predisposition to two diseases caused by hepatitis C and tick-borne encephalitis viruses in Russian population.

Keywords: Chronic hepatitis C; Human genetic predisposition; Interleukin 10 (IL10) gene; Interleukin 28B (IL28B) gene; Single nucleotide polymorphism (SNP); Tick-borne encephalitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Alleles
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Hepatitis C, Chronic / epidemiology
  • Hepatitis C, Chronic / genetics*
  • Humans
  • Interleukin-10 / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic
  • Russia / epidemiology
  • Young Adult

Substances

  • IL10 protein, human
  • Interleukin-10