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Sci Rep. 2017 Dec 15;7(1):17661. doi: 10.1038/s41598-017-17546-0.

Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.

Author information

1
Center of Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Barcelona, Spain. selenatasoy@gmail.com.
2
Psychedelic Research Group, Psychopharmacology Unit, Centre for Psychiatry, Department of Medicine, Imperial College London, London, UK.
3
Department of Psychiatry, University of Oxford, Oxford, UK.
4
Center for Music in the Brain, Clinical Medicine, Aarhus University, Aarhus, Denmark.
5
Center of Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Barcelona, Spain.
6
Institució Catalana de la Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
7
Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
8
School of Psychological Sciences, Monash University, Melbourne, Australia.

Abstract

Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used 'connectome-harmonic decomposition', a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.

PMID:
29247209
PMCID:
PMC5732294
DOI:
10.1038/s41598-017-17546-0
[Indexed for MEDLINE]
Free PMC Article

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