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J Pediatr. 2018 Jan;192:80-85.e1. doi: 10.1016/j.jpeds.2017.09.071.

The Association of Breastfeeding Duration and Early Childhood Cardiometabolic Risk.

Collaborators (140)

Lau E6, Laupacis A6, Salter M6, Szatmari P6, Weir S6, Camacho C7, Chandraraj A7, Dalwadi D7, Islam A7, Jegathesan T7, Malhi T7, Smith M7, Thompson L7, Allen C8, Boodhoo B8, Hall J8, Juni P8, Lebovic G8, Pope K8, Shim J8, Thorpe K8, Azad A9, Abdullah K10, Ali Y10, Bayoumi I10, Borkhoff CM10, Carsley S10, Chen S10, Chen Y10, Darmawikarta D10, Dennis CL10, Eny K10, Erdle S10, Furlong K10, Kavikondala K10, Koroshegyi C10, Kowal C10, Lee GJ10, Mason D10, Omand J10, Persaud N10, Plumptre L10, van den Heuvel M10, Vanderhout S10, Zabih W10, Abdurrahman M11, Anderson B11, Anderson K11, Arbess G11, Baker J11, Barozzino T11, Bergeron S11, Bhagat D11, Blanchette N11, Bloch G11, Bonifacio J11, Bowry A11, Brown A11, Bugera J11, Campbell D11, Cheema S11, Cheng E11, Chisamore B11, Culbert E11, Danayan K11, Das P11, Derocher MB11, Do A11, Dorey M11, Doukas K11, Egger A11, Farber A11, Freedman A11, Freeman S11, Fung K11, Gazeley S11, Guiang C11, Ha D11, Handford C11, Hanson L11, Hatch H11, Hughes T11, Jacobson S11, Jagiello L11, Jansz G11, Kadar P11, Kiran T11, Kitney L11, Knowles H11, Kwok B11, Lakhoo S11, Lam-Antoniades M11, Lau E11, Leung FH11, Li A11, Loo J11, Louis J11, Mahmoud S11, Male R11, Mascoll V11, Moodie R11, Morinis J11, Nader M11, Naymark S11, Neelands P11, Owen J11, Parry J11, Peer M11, Pena K11, Perlmutar M11, Persaud N11, Pinto A11, Pitt T11, Porepa M11, Qi V11, Ramji N11, Ramji N11, Rana J11, Rosenthal A11, Rouleau K11, Saunderson J11, Saxena R11, Schiralli V11, Sgro M11, Shuja H11, Shepherd S11, Shuja H11, Smiltnieks B11, Srikanthan C11, Taylor C11, Turner S11, Uddin F11, Vaughan J11, Weisdorf T11, Wijayasinghe S11, Wormsbecker A11, Ying E11, Young E11, Zajdman M11, Zenlea I11.

Author information

1
Division of Pediatric Medicine, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Hospital for Sick Children Research Institute, Toronto, Ontario, Canada. Electronic address: peter.wong@sickkids.ca.
2
Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
3
Department of Pediatrics, St. Michael's Hospital and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
4
Division of Pediatric Medicine, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
5
Division of Pediatric Medicine, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Hospital for Sick Children Research Institute, Toronto, Ontario, Canada; Department of Pediatrics, St. Michael's Hospital and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada.
6
Advisory Committee.
7
Research Team.
8
Applied Health Research Center.
9
Mount Sinai Services Laboratory.
10
Scientific Committee.
11
Site Investigators.

Abstract

OBJECTIVE:

To evaluate the association between breastfeeding duration and early childhood cardiometabolic risk.

STUDY DESIGN:

A cross-sectional study of 1539 healthy children, 3-6 years of age, recruited through The Applied Research Group for Kids! practice-based research network between October 2009 and August 2015. Adjusted multivariable linear regression was used to examine the association between breastfeeding duration and cardiometabolic risk z score and individual cardiometabolic risk factors of waist circumference, systolic blood pressure, glucose, high-density lipoprotein cholesterol, and triglycerides.

RESULTS:

The mean breastfeeding duration was 12.5 months (SD = 8.4). Breastfeeding duration was associated with lower cardiometabolic risk z score (beta = -0.03; 95% CI -0.05, -0.01). In analysis of cardiometabolic risk factors, each additional 3 months of breastfeeding was associated with a 0.13 cm (95% CI -0.20, -0.05) lower waist circumference and 0.16 mm Hg (95% CI -0.30, -0.02) lower systolic blood pressure. Compared with children who breastfed for 6-12 months, those who breastfed for 12-24 months had a lower systolic blood pressure of 1.07 mm Hg (95% CI -2.04, -0.10). There was no association between breastfeeding duration and cardiometabolic risk for those who breastfed beyond 24 months.

CONCLUSIONS:

Breastfeeding duration is associated with lower cardiometabolic risk, although the magnitude of association is small. Causation cannot be inferred. Breastfeeding beyond 24 months may not have an added benefit for cardiometabolic health.

KEYWORDS:

healthy child; heart disease; infant feeding

PMID:
29246362
DOI:
10.1016/j.jpeds.2017.09.071
[Indexed for MEDLINE]

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