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J Pediatr. 2018 Jan;192:53-59.e2. doi: 10.1016/j.jpeds.2017.09.021.

Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants.

Collaborators (150)

Polin RA9, Keszler M10, Vohr BR10, Hensman AM10, Vieira E10, Little E10, Fanaroff AA11, Hibbs AM11, Newman NS11, Siner BS11, Truog WE12, Pallotto EK12, Kilbride HW12, Gauldin C12, Holmes A12, Johnson K12, Schibler K13, Kallapur SG13, Grisby C13, Alexander B13, Fischer EE13, Jackson L13, Kirker K13, Jennings J13, Wuertz S13, Muthig G13, Donovan EF13, Hessling J13, Mersmann MW13, Mincey HL13, Cotten CM14, Goldberg RN14, Finkle J14, Fisher KA14, Auten KJ14, Laughon MM14, Bose CL14, Bernhardt J14, Clark C14, Stoll BJ15, Carlton DP15, Hale EC15, Loggins Y15, Bottcher DI15, Archer SW16, Wright LL16, McClure EM16, Poindexter BB17, Sokol GM17, Herron DE17, Lemons JA17, Appel DD17, Miller LC17, Sanchez PJ18, Nelin LD18, Jadcherla SR18, Luzader P18, Parikh NA18, Nist MD18, Fuller J18, Gutentag J18, Jones ME18, McGregor S18, Rodgers E18, Ulloa JA18, Wolfe T18, Das A6, Wallace D6, Poole WK6, Zaterka-Baxter KM6, Crawford M6, Gabrio J6, O'Donnell Auman J6, Huitema CP6, Hastings BK6, Van Meurs KP19, Stevenson DK19, Ball MB19, Proud MS19, Carlo WA20, Ambalavanan N20, Collins MV20, Cosby SS20, Devaskar U21, Garg M21, Chanlaw T21, Geller R21, Colaizy TT22, Ellsbury DL22, Brumbaugh JE22, Johnson KJ22, Campbell DB22, Walker JR22, Watterberg KL23, Ohls RK23, Lacy CB23, Beauman SS23, Hartenberger C23, Schmidt B24, Kirpalani H24, Cook N24, DeMauro SB24, Chaudhary AS24, Abbasi S24, Mancini T24, Cucinotta D24, D'Angio CT25, Guillet R25, Lakshminrusimha S25, Phelps DL25, Reynolds AM25, Hunn J25, Jensen R25, Wadkins HIM25, Guilford S25, Williams A25, Sacilowski M25, Reubens L25, Burnell E25, Rowan M25, Wynn K25, Maffett D25, Brion LP26, Vasil DM26, Chen L26, Torres LE26, Salhab WA26, Madison S26, Hensley G26, Miller NA26, Guzman A26, Kennedy KA27, Tyson JE27, Arldt-McAlister J27, Garcia C27, Martin K27, McDavid GE27, Wright SL27, Akpa EG27, Cluff PA27, Lis AE27, Franco CI27, Pappas A28, Barks J28, Bara R28, Handel S28, Muran G28, White DF28, Christensen M28, Wiggins SA28.

Author information

1
Department of Pediatrics, Brown University, Providence, RI. Electronic address: alaptook@wihri.org.
2
Department of Pediatrics, University of Iowa, Iowa City, IA.
3
Department of Pediatrics, Wayne State University, Detroit, MI.
4
Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC.
5
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
6
RTI International, Research Triangle Park, NC.
7
Department of Pediatrics, Case Western Reserve, Cleveland, OH.
8
Pregnancy and Perinatology Branch, National Institute of Child Health and Human Development, Bethesda, MD.
9
NRN Steering Committee Chair, Division of Neonatology, College of Physicians and Surgeons, Columbia University, New York, NY.
10
Alpert Medical School of Brown University and Women & Infants Hospital of Rhode Island, Providence, RI.
11
Case Western Reserve University, Rainbow Babies & Children's Hospital, Cleveland, OH.
12
Children's Mercy Hospital, Kansas City, MO.
13
Cincinnati Children's Hospital Medical Center, University of Cincinnati Medical Center, Good Samaritan Hospital, Cincinnati, OH.
14
Duke University School of Medicine, University Hospital, University of North Carolina, Duke Regional Hospital, Durham, NC.
15
Emory University, Children's Healthcare of Atlanta, Grady Memorial Hospital, Emory University Hospital Midtown, Atlanta, GA.
16
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
17
Indiana University, University Hospital, Methodist Hospital, Riley Hospital for Children at Indiana University Health, Eskenazi Health, Indianapolis, IN.
18
Nationwide Children's Hospital and the Ohio State University Medical Center, Columbus, OH.
19
Stanford University and Lucile Packard Children's Hospital, Palo Alto, CA.
20
University of Alabama at Birmingham Health System and Children's Hospital of Alabama, Birmingham, AL.
21
University of California - Los Angeles, Mattel Children's Hospital, Santa Monica Hospital, Los Robles Hospital and Medical Center, Olive View Medical Center, Los Angeles, CA.
22
University of Iowa and Mercy Medical Center, Iowa City, IA.
23
University of New Mexico Health Sciences Center, Albuquerque, NM.
24
University of Pennsylvania, Hospital of the University of Pennsylvania, Pennsylvania Hospital, Children's Hospital of Philadelphia, Philadelphia, PA.
25
University of Rochester Medical Center, Golisano Children's Hospital, University of Buffalo Women's and Children's Hospital of Buffalo, Rochester, NY.
26
University of Texas Southwestern Medical Center at Dallas, Parkland Health & Hospital System, Children's Medical Center Dallas, Dallas, TX.
27
University of Texas Health Science Center at Houston Medical School, Children's Memorial Hermann Hospital, Lyndon Baines Johnson General Hospital, Memorial Hermann Southwest Hospital, Houston, TX.
28
Wayne State University, University of Michigan, Hutzel Women's Hospital, Children's Hospital of Michigan, Detroit, MI.

Abstract

OBJECTIVE:

To evaluate the temperature distribution among moderately preterm (MPT, 29-33 weeks) and extremely preterm (EPT, <29 weeks) infants upon neonatal intensive care unit (NICU) admission in 2012-2013, the change in admission temperature distribution for EPT infants between 2002-2003 and 2012-2013, and associations between admission temperature and mortality and morbidity for both MPT and EPT infants.

STUDY DESIGN:

Prospectively collected data from 18 centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network were used to examine NICU admission temperature of inborn MPT and EPT infants. Associations between admission temperature and mortality and morbidity were determined by multivariable logistic regression. EPT infants from 2002-2003 and 2012-2013 were compared.

RESULTS:

MPT and EPT cohorts consisted of 5818 and 3213 infants, respectively. The distribution of admission temperatures differed between the MPT vs EPT (P < .01), including the percentage <36.5°C (38.6% vs 40.9%), 36.5°C-37.5°C (57.3% vs 52.9%), and >37.5°C (4.2% vs 6.2%). For EPT infants in 2012-2013 compared with 2002-2003, the percentage of temperatures between 36.5°C and 37.5°C more than doubled and the percentage of temperatures >37.5°C more than tripled. Admission temperature was inversely associated with in-hospital mortality.

CONCLUSIONS:

Low and high admission temperatures are more frequent among EPT than MPT infants. Compared with a decade earlier, fewer EPT infants experience low admission temperatures but more have elevated temperatures. In spite of a change in distribution of NICU admission temperature, an inverse association between temperature and mortality risk persists.

KEYWORDS:

hyperthermia; hypothermia; prematurity; survival

PMID:
29246358
PMCID:
PMC5808888
DOI:
10.1016/j.jpeds.2017.09.021
[Indexed for MEDLINE]
Free PMC Article

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