Format

Send to

Choose Destination
Cell. 2017 Dec 14;171(7):1471. doi: 10.1016/j.cell.2017.12.002.

CD19 CAR T Cells.

Author information

1
Center for Cell Engineering, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA. Electronic address: m-sadelain@ski.mskcc.org.

Abstract

CARs are synthetic receptors that reprogram immune cells for therapeutic purposes. They comprise three canonical domains for antigen recognition, T cell activation, and costimulation. The CAR cDNA is genetically integrated in the T cell genome. Autologous CAR T cells are generated from the patient's peripheral blood T cells and expand in the recipient to eliminate the targeted tumor. To view this Bench to Bedside, open or download the PDF.

PMID:
29245005
DOI:
10.1016/j.cell.2017.12.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center