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Nutr Cancer. 2018 Jan;70(1):51-60. doi: 10.1080/01635581.2018.1397707. Epub 2017 Dec 15.

Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study.

Author information

1
a Department of Surgery , University Clinic of Heidelberg , Heidelberg , Germany.
2
b Division of Preventive Oncology , National Center for Tumor Diseases and German Cancer Research Center , Heidelberg , Germany.
3
c German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) , Heidelberg , Germany.
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d Department of Epidemiology , German Institute of Human Nutrition , Potsdam-Rehbrücke , Germany.
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e Division of Epigenomics and Cancer Risk Factors , German Cancer Research Center (DKFZ) , Heidelberg , Germany.
6
f Population Sciences, Huntsman Cancer Institute , Salt Lake City , Utah , USA.
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g Genome Biology Unit, European Molecular Biology Laboratory , Heidelberg , Germany.
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h Institute of Medical Biometry and Informatics, University of Heidelberg , Heidelberg , Germany.
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i Division of Clinical Epidemiology and Aging Research , German Cancer Research Center (DKFZ) , Heidelberg , Germany.
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j Division of Cancer Epidemiology , German Cancer Research Center , Heidelberg , Germany.
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k Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , Washington , USA.
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l Department of Health Outcomes and Behavior , Moffitt Cancer Center , Tampa , Florida , USA.
13
m Cancer Prevention Program, Fred Hutchinson Cancer Research Center , Seattle , Washington , USA.

Abstract

Quality of life (QoL) is an important clinical outcome in cancer patients. We investigated associations between dietary patterns and QoL changes in colorectal cancer (CRC) patients. The study included 192 CRC patients with available EORTC QLQ-C30 data before and 12 months post-surgery and food frequency questionnaire data at 12 months post-surgery. Principal component analysis was used to identify dietary patterns. Multivariate regression models assessed associations between dietary patterns and QoL changes over time. We identified four major dietary patterns: "Western" dietary pattern characterized by high consumption of potatoes, red and processed meat, poultry, and cakes, "fruit&vegetable" pattern: high intake of vegetables, fruits, vegetable oils, and soy products, "bread&butter" pattern: high intake of bread, butter and margarine, and "high-carb" pattern: high consumption of pasta, grains, nonalcoholic beverages, sauces and condiments. Patients following a "Western" diet had lower chances to improve in physical functioning (OR = 0.45 [0.21-0.99]), constipation (OR = 0.30 [0.13-0.72]) and diarrhea (OR: 0.44 [0.20-0.98]) over time. Patients following a "fruit&vegetable" diet showed improving diarrhea scores (OR: 2.52 [1.21-5.34]. A "Western" dietary pattern after surgery is inversely associated with QoL in CRC patients, whereas a diet rich in fruits and vegetables may be beneficial for patients' QoL over time.

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