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Eur J Nutr. 2019 Feb;58(1):315-324. doi: 10.1007/s00394-017-1595-8. Epub 2017 Dec 14.

Effects of hydration on plasma copeptin, glycemia and gluco-regulatory hormones: a water intervention in humans.

Author information

1
Department of Endocrinology, Skåne University Hospital, Lund University, Malmö, Sweden. sofia.enhorning@med.lu.se.
2
Department of Clinical Sciences, Lund University, Malmö, Sweden. sofia.enhorning@med.lu.se.
3
Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Jan Waldenströms gata 35, 91:12, 205 02, Malmö, Sweden. sofia.enhorning@med.lu.se.
4
Department of Anesthesiology, Skåne University Hospital, Lund University, Malmö, Sweden.
5
Department of Clinical Sciences, Lund University, Malmö, Sweden.
6
INSERM, Unit 1138, Centre de Recherche des Cordeliers, Paris, France.
7
Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, Paris, France.
8
Assistance Publique Hôpitaux de Paris, Hôpital Bichat, DHU FIRE, Paris, France.
9
University Pierre et Marie Curie, Centre de Recherche des Cordeliers, Paris, France.
10
Department of Internal Medicine, Skåne University Hospital, Lund University, Malmö, Sweden.

Abstract

PURPOSE:

High plasma copeptin, a marker of vasopressin, predicts diabetes mellitus. We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon.

METHODS:

Thirty-nine healthy individuals underwent, in random order, 1 week of high water intake (3 L/day on top of habitual intake) and 1 week of normal (habitual) fluid intake (control). Fasting plasma concentrations of copeptin, glucose, insulin and glucagon were compared between the ends of both periods. Furthermore, acute copeptin kinetics were mapped for 4 h after ingestion of 1 L of water.

RESULTS:

After acute intake of 1 L water, copeptin was significantly reduced within 30 min, and reached maximum reduction within 90 min with on average 39% reduction (95% confidence interval (95 CI) 34-45) (p < 0.001) and remained low the entire test period (4 h). One week of increased water intake led to a 15% reduction (95 CI 5-25) (p = 0.003) of copeptin compared to control week. The greatest reduction occurred among subjects with habitually high copeptin and concentrated urine ("water-responders"). Water-responders had significant water-induced reduction of glucagon, but glucose and insulin were unaffected.

CONCLUSIONS:

Both acute and 1 week extra water intake potently reduced copeptin concentration. In those with the greatest decline (water-responders), who are typically low drinkers with high baseline copeptin, water induced a reduction in fasting glucagon. Long-term trials assessing the effect of water on glucometabolic traits should focus on low-water drinkers with high copeptin concentration.

KEYWORDS:

Glucagon; Insulin; OGTT; Vasopressin; Water

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