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Clin J Am Soc Nephrol. 2018 Jan 6;13(1):140-152. doi: 10.2215/CJN.09030817. Epub 2017 Dec 14.

Lessons from CKD-Related Genetic Association Studies-Moving Forward.

Limou S1,2,3,4, Vince N1,2, Parsa A5,6.

Author information

1
Centre de Recherche en Transplantation et Immunologie Unité Mixte de Recherche 1064, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Nantes, Nantes, France.
2
Institut de Transplantation Urologie et Néphrologie, Centre Hospitalier Universitaire Nantes, Nantes, France.
3
Ecole Centrale de Nantes, Nantes, France.
4
Basic Science Program, Basic Research Laboratory, National Cancer Institute/National Institutes of Health, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, Maryland.
5
Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland; and aparsa@medicine.umaryland.edu.
6
Department of Medicine, Baltimore VA Medical Center, Baltimore, Maryland.

Abstract

Over the past decade, genetic association studies have uncovered numerous determinants of kidney function in the general, diabetic, hypertensive, CKD, ESRD, and GN-based study populations (e.g., IgA nephropathy, membranous nephropathy, FSGS). These studies have led to numerous novel and unanticipated findings, which are helping improve our understanding of factors and pathways affecting both normal and pathologic kidney function. In this review, we report on major discoveries and advances resulting from this rapidly progressing research domain. We also predict some of the next steps the nephrology community should embrace to accelerate the identification of genetic and molecular processes leading to kidney dysfunction, pathophysiologically based disease subgroups, and specific therapeutic targets, as we attempt to transition toward a more precision-based medicine approach.

KEYWORDS:

Genetic Association Studies; Hypertension, Renal; Hypertensive Nephropathy; Kidney Failure, Chronic; Renal Insufficiency, Chronic; chronic kidney disease; diabetes mellitus; genetic renal disease; genome wide association; glomerulonephritis; nephritis; nephrology; precision medicine; systems biology

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