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Cell Host Microbe. 2017 Dec 13;22(6):724-725. doi: 10.1016/j.chom.2017.11.011.

Plasmodium Peekaboo: PK4 Mediates Parasite Latency.

Author information

1
School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
2
The Francis Crick Institute, London, UK.
3
School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK. Electronic address: rita.tewari@nottingham.ac.uk.

Abstract

In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.

PMID:
29241036
DOI:
10.1016/j.chom.2017.11.011
[Indexed for MEDLINE]
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