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CPT Pharmacometrics Syst Pharmacol. 2018 Jan;7(1):34-41. doi: 10.1002/psp4.12264. Epub 2017 Dec 14.

Crowdsourced Asparagus Urinary Odor Population Kinetics.

Author information

1
Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
2
Pharmacokinetics, Pharmacodynamics, Modeling & Simulation, ICON Plc, Cary, North Carolina, USA.
3
Cluster Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
4
PD-Value BV, Houten, The Netherlands.
5
Clinical Pharmacology, Modeling and Simulation, Amgen Inc, Thousand Oaks, California, USA.
6
Pharmacokinetics, Pharmacodynamics, Modeling & Simulation, ICON Plc, Marlow, UK.
7
Certara QSP, Canterbury, UK.
8
Takeda Pharmaceuticals International Co, Cambridge, Massachusetts, USA.

Abstract

The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV). To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with consenting attendees from two American Society for Clinical Pharmacology and Therapeutics (ASCPT) meetings. Subjects were randomized to eat a specific number of asparagus spears, and then asked to report their urinary odor perception. Eighty-seven subjects were included in the final analysis. A mixed effect proportional odds model was developed that adequately characterized the dose-response relationship. We estimated the half-life of the asparagus effect on malodorous urine to be 4.7 hours (relative standard error (RSE) = 13.2%), and identified a dose-response slope term with good precision (24.3%). Age was found as the predictor of IIV in slope estimates. This study design and tools can be used as a demonstration "crowdsourcing" project for studying population kinetics in organizational and educational settings.

PMID:
29239147
PMCID:
PMC5784735
DOI:
10.1002/psp4.12264
[Indexed for MEDLINE]
Free PMC Article

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