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Exp Gerontol. 2018 Feb;102:109-132. doi: 10.1016/j.exger.2017.12.005. Epub 2017 Dec 10.

The association between C-reactive protein, Interleukin-6 and depression among older adults in the community: A systematic review and meta-analysis.

Author information

1
Department of Psychological Sciences, School of Psychology, Faculty of Health and Medicine, University of Surrey, Guildford, UK. Electronic address: Kimberley.j.smith@surrey.ac.uk.
2
Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada.
3
Department of Psychological Sciences, School of Psychology, Faculty of Health and Medicine, University of Surrey, Guildford, UK.
4
Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Montreal Diabetes Research Center, Montreal, Quebec, Canada.

Abstract

Previous research indicates there may be an association between inflammation and depression in older adults but results are inconsistent. Therefore, the aim of this review was to determine the cross-sectional and longitudinal associations of two inflammatory markers C-reactive protein (CRP) and Interleukin-6 (IL-6) with depression in older adults. We searched five databases for cross-sectional and longitudinal studies reporting an association between CRP or IL-6 with depression among adults sampled from the community aged 50 or older. We found 32 studies (23 cross-sectional, 7 longitudinal, and 2 assessing both cross-sectional and longitudinal associations) that met eligibility criteria. These studies were entered into a random-effects meta-analysis to determine the cross-sectional association and longitudinal direction of association between both IL-6 and CRP with depression. Results indicated a cross-sectional and longitudinal association between both CRP and IL-6 with depression in older adults, with inflammation leading to depression in longitudinal studies rather than depression to inflammation. However, there was notable heterogeneity between studies as results differed based on adjusting for confounders and on how inflammation and depression were measured. These sources of heterogeneity could explain differences in study results.

KEYWORDS:

C-reactive protein; Depression; Interleukin-6; Meta-analysis; Older adults; Systematic review

PMID:
29237576
DOI:
10.1016/j.exger.2017.12.005
[Indexed for MEDLINE]

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