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Ann Med. 2018 Mar;50(2):121-127. doi: 10.1080/07853890.2017.1417631. Epub 2017 Dec 18.

The role of mitochondrial dysfunction in cardiovascular disease: a brief review.

Author information

1
a Department of Neurochemistry, Division of Basic and Applied Neurobiology , Serbsky Federal Medical Research Center of Psychiatry and Narcology , Moscow , Russia.
2
b Department of Genetics, Southern Federal University , Rostov-on-Don , Russia.
3
c Laboratory of Angiopathology , Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences , Moscow , Russia.
4
d Federal Scientific Clinical Center for Resuscitation and Rehabilitation , Moscow , Russia.
5
e Laboratory of Angiopathology , Institute of General Pathology and Pathophysiology, Russian Academy of Sciences , Moscow , Russia.
6
f Institute for Atherosclerosis Research, Skolkovo Innovative Center , Moscow , Russia.

Abstract

Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Proper mitochondrial function is necessary in tissues and organs that are of high energy demand, including the heart. Mitochondria are very sensitive to nutrient and oxygen supply and undergo metabolic adaptation to the changing environment. In CVD, such an adaptation is impaired, which, in turn, leads to a progressive decline of the mitochondrial function associated with abnormalities in the respiratory chain and ATP synthesis, increased oxidative stress, and loss of the structural integrity of mitochondria. Uncoupling of the electron transport chain in dysfunctional mitochondria results in enhanced production of reactive oxygen species, depletion of cell ATP pool, extensive cell damage, and apoptosis of cardiomyocytes. Mitophagy is a process, during which cells clear themselves from dysfunctional and damaged mitochondria using autophagic mechanism. Deregulation of this process in the failing heart, accumulation of dysfunctional mitochondria makes the situation even more adverse. In cardiac pathology, aberrations of the activity of the respiratory chain and ATP production may be considered as a core of mitochondrial dysfunction. Indeed, therapeutic restoration of these key functional properties can be considered as a primary goal for improvement of mitochondrial dysfunction in CVD. Key messages Mitochondrial dysfunction plays a crucial role in cardiovascular disease pathogenesis. Cardiovascular disease is associated with altered mithochondrial biogenesis and clearance. In cardiovascular disease, impaired mitochondrial function results in decreased ATP production and enhanced ROS formation.

KEYWORDS:

ATP depletion; Mitochondrial dysfunction; apoptosis; autophagy; cardiovascular disease; oxidative stress

PMID:
29237304
DOI:
10.1080/07853890.2017.1417631
[Indexed for MEDLINE]

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