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Schizophr Bull. 2018 Aug 20;44(5):1151-1158. doi: 10.1093/schbul/sbx165.

Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966.

Author information

1
Center for Life Course Health Research, University of Oulu, Finland.
2
Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland.
3
Institute of Clinical Medicine (Psychiatry), University of Eastern Finland, Finland.
4
Department of Psychiatry, Kuopio University Hospital, Finland.
5
South-Savonia Hospital District, Finland.
6
North Karelia Central Hospital, Finland.
7
SOTE, Finland.
8
Lapland Central Hospital, Finland.
9
Department of Psychiatry, University of Cambridge, UK.
10
Cambridgeshire and Peterborough NHS Foundation Trust, UK.
11
Biocenter Oulu, University of Oulu, Finland.
12
Center for Clinical Neurosciences, Department of Psychiatry, University of Oulu, Finland.
13
PEDEGO Research Unit, Child Psychiatry, University of Oulu, Finland.
14
Clinic of Child Psychiatry, University Hospital of Oulu, Finland.
15
Department of Psychiatry, Oulu University Hospital, Finland.

Abstract

Delayed motor developmental milestones have been reported to be associated with schizophrenia in previous studies, but no study has examined the relationship between early motor developmental milestones and schizotypy. We have examined this relationship in a prospective birth cohort.In the Northern Finland Birth Cohort 1966, data on 9 early motor developmental milestones were collected prospectively from visits to child welfare centers, and data on adult schizotypy were collected through a questionnaire (N = 4557-4674). Positive schizotypy was measured by the Perceptual Aberration Scale (PAS), negative schizotypy was measured by Physical Anhedonia Scale (PhAS) and Social Anhedonia Scale (SAS). Three related scales were included: Schizoidia Scale (SCHD), Hypomanic Personality Scale (HPS), and Bipolar II Scale (BIP2). We examined the milestone-schizotypy associations before and after excluding cases of schizophrenia from this population-based sample. Hierarchical regression analyses adjusted for covariates and separately for both genders were performed. In men, each extra month of delay in achievement of touching thumb with index finger, sitting unsupported, standing up, walking with support, or walking unsupported was associated with an increase in PAS, PhAS, or SCHD scores, or decrease in BIP2 score (P < .05). In women, each extra month of delay in achievement of turning from back to tummy was associated with an increase in PhAS and SAS scores (P < .05). Schizotypy is associated with delayed motor developmental milestones in early-life, but there is some heterogeneity with regards to types of milestones and gender. These findings suggest delayed motor development confers risk across the continuum of schizophrenia syndrome.

PMID:
29237066
PMCID:
PMC6101480
DOI:
10.1093/schbul/sbx165
[Indexed for MEDLINE]
Free PMC Article

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