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Eur Heart J Cardiovasc Imaging. 2018 Jul 1;19(7):768-776. doi: 10.1093/ehjci/jex309.

Comparison of MOLLI, shMOLLLI, and SASHA in discrimination between health and disease and relationship with histologically derived collagen volume fraction.

Author information

1
Department of Cardiology, Guys and St Thomas' NHS Trust, Westminster Bridge Road, London, UK.
2
Cardiovascular Division, King's College London, The Rayne Institute. St Thomas' Hospital, Westminster Bridge Road, London SE5 9RS, UK.
3
Department of Cardiology, King's College Hospital NHS Trust, Denmark Hill, London, UK.
4
Department of Radiology, University of Bonn, Regina-Pacis-Weg 3, Bonn, Germany.
5
Department of Cardiology, University of Hospital, Paseo de la Castellana, La Paz, Madrid, Spain.
6
Department of Cardiothoracic Surgery, Queen Alexandra Hospital, Guys and St Thomas' NHS Trust, Westminster Bridge Road, London, UK.
7
Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, UK.
8
Department of Cardiology, Portsmouth Hospitals NHS Trust, Southwick Hill Road, Portsmouth, UK.
9
Institute for Cardiovascular Regeneration, University of Frankfurt, German Centre of Cardiovascular Research, (DZHK), Theodor-Stern-Kai 7, Frankfurt, Germany.
10
Institute of Experimental and Translational Cardiovascular Imaging, Goethe University Hospital Frankfurt, German Centre of Cardiovascular Research, (DZHK), Theodor-Stern-Kai 7, Frankfurt, Germany.
11
Department of Cardiology, Goethe University Hospital Frankfurt, German Centre of Cardiovascular Research, (DZHK), Theodor-Stern-Kai 7, Frankfurt, Germany.

Abstract

Aims:

To determine the bioequivalence of several T1 mapping sequences in myocardial characterization of diffuse myocardial fibrosis.

Methods and results:

We performed an intra-individual sequence comparison of three types of T1 mapping sequences [MOdified Look-Locker Inversion recovery (MOLLI), Shortened MOdified Look-Locker Inversion recovery ((sh)MOLLI), and SAturation recovery single-SHot Acquisition (SASHA)]. We employed two model diseases of diffuse interstitial fibrosis [patients with non-ischaemic dilated cardiomyopathy (NIDCM), n = 32] and aortic stenosis [(AS), n = 25)]. Twenty-six healthy individuals served as controls. Relationship with collagen volume fraction (CVF) was assessed using endomyocardial biopsies (EMB) intraoperatively in 12 AS patients. T2 mapping (GraSE) was also performed. Myocardial native T1 with MOLLI and shMOLLI showed, firstly, an excellent discriminatory accuracy between health and disease [area under the curves (P-value): 0.94 (0.88-0.99); 0.87 (0.79-0.94); 0.61 (0.49-0.72)], secondly, relationship between histological CVF [native T1 MOLLI vs. shMOLLI vs. SASHA: r = 0.582 (P = 0.027), r = 0.524 (P = 0.046), r = 0.443 (P = 0.150)], and thirdly, with native T2 [r = 0.628(P < 0.001), r = 0.459 (P = 0.003), r = 0.211 (P = 0.083)]. The respective relationships for extracellular volume fraction with CVF [r = 0.489 (P = 0.044), r = 0.417 (0.071), r = 0.353 (P = 0.287)] were significant for MOLLI, but not other sequences. In AS patients, native T2 was significantly higher compared to controls, and associated with levels of C-reactive protein and troponin.

Conclusion:

T1 mapping sequences differ in their bioequivalence for discrimination between health and disease as well as associations with diffuse myocardial fibrosis.

PMID:
29237044
DOI:
10.1093/ehjci/jex309

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