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PLoS One. 2017 Dec 13;12(12):e0189289. doi: 10.1371/journal.pone.0189289. eCollection 2017.

Treatment following myocardial infarction in patients with schizophrenia.

Author information

Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark.
Unit of Clinical Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark.



A correlation between excess mortality from myocardial infarctions (MI) and schizophrenia has already been established. What remains unclear is whether the initial communication between the treating doctor and the corresponding patient contributes to this excess mortality.


The aim of this study is to investigate whether a patient with schizophrenia receives the same offers for examination and treatment following a MI compared to a psychiatric healthy control (PHC).


This cohort study includes patients diagnosed with schizophrenia at the time of their first MI (n = 47) in the years between 1995-2015 matched 1:2 to psychiatric healthy MI patients on gender, age and year of first MI. All existing hospital files for the 141 patients were thoroughly reviewed and the number of offered and accepted examinations and treatments were extracted for comparisons between the two groups.


In general patients with schizophrenia were less likely to be offered and accept examination and at the same time be offered and accept treatment as compared to PHCs (p<0.01). In addition, there was a statistical trend towards patients with schizophrenia being more likely to decline examination (p = 0.10) and decline treatment (p = 0.09) compared to PHCs, while being offered examination and being offered treatment both contributed statistically insignificantly to the overall discrepancy between the two patient groups.


Being diagnosed with schizophrenia limits the treatment received following a first MI compared to PHCs. However, we are unable to pinpoint, whether Physician bias, patient's unwillingness to receive health care or both contribute to the excess mortality seen in these comorbid patients.

[Indexed for MEDLINE]
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