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Anat Rec (Hoboken). 2018 May;301(5):862-886. doi: 10.1002/ar.23751. Epub 2018 Jan 6.

Species Differences in the Organization of the Ventral Cochlear Nucleus.

Author information

1
Department of Physiology and Biophysics, University at Buffalo, Buffalo, New York.
2
Department of Communicative Disorders and Sciences, Center for Hearing and Deafness, University at Buffalo, Buffalo, New York.
3
Department of Anthropology, The George Washington University, Washington, DC.
4
Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
5
Department of Physiology, Northwestern University Medical School, Chicago, Illinois.
6
Department of Psychiatry and Behavioural Neurosciences, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.

Abstract

The mammalian cochlear nuclei (CN) consist of two major subdivisions, the dorsal (DCN) and ventral (VCN) nuclei. We previously reported differences in the structural and neurochemical organization of the human DCN from that in several other species. Here we extend this analysis to the VCN, considering both the organization of subdivisions and the types and distributions of neurons. Classically, the VCN in mammals is composed of two subdivisions, the anteroventral (VCA) and posteroventral cochlear nuclei (VCP). Anatomical and electrophysiological data in several species have defined distinct neuronal types with different distributions in the VCA and VCP. We asked if VCN subdivisions and anatomically defined neuronal types might be distinguished by patterns of protein expression in humans. We also asked if the neurochemical characteristics of the VCN are the same in humans as in other mammalian species, analyzing data from chimpanzees, macaque monkeys, cats, rats and chinchillas. We examined Nissl- and immunostained sections, using antibodies that had labeled neurons in other brainstem nuclei in humans. Nissl-stained sections supported the presence of both VCP and VCA in humans and chimpanzees. However, patterns of protein expression did not differentiate classes of neurons in humans; neurons of different soma shapes and dendritic configurations all expressed the same proteins. The patterns of immunostaining in macaque monkey, cat, rat, and chinchilla were different from those in humans and chimpanzees and from each other. The results may correlate with species differences in auditory function and plasticity. Anat Rec, 301:862-886, 2018.

KEYWORDS:

audition; chimpanzees; cochlea; human

PMID:
29236365
PMCID:
PMC5902649
[Available on 2019-05-01]
DOI:
10.1002/ar.23751

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