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Proteomics. 2018 Jan;18(2). doi: 10.1002/pmic.201700361.

Proteomics in Pathology.

Author information

1
Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
2
Proteopath GmbH, Trier, Germany.
3
Institute of Pathology, Technical University of Munich, Munich, Germany.
4
Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
5
Clinical Cooperation Unit Neuropathology, German Cancer Center, Heidelberg, Germany.
6
Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
7
Center for Histology, Cytology and Molecular Diagnostics, Trier, Germany.

Abstract

Proteomic approaches are of growing importance in the biologist's toolbox. It greatly benefited from past and recent advances in sampling, chemical processing, mass spectrometry (MS) instrumentation, and data processing. MS-based analysis of proteins is now in the process of being translated in pathology for objective diagnoses. In this viewpoint, we present the workflows that we think are the most promising for applications in pathology. We also comment what we think are prerequisites for a successful translational implementation.

KEYWORDS:

Biomarker discovery; Diagnostics; Molecular pathology; Tissue typing; Transnational proteomics

PMID:
29236356
DOI:
10.1002/pmic.201700361
[Indexed for MEDLINE]

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