Send to

Choose Destination
Biochem Biophys Res Commun. 1989 Feb 28;159(1):249-55.

Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF).

Author information

Research Laboratories, Dainippon Pharmaceutical Co. Ltd., Suita/Osaka, Japan.


cDNA clones having a nucleotide sequence encoding a human monocyte chemotactic and activating factor (MCAF) were isolated and sequenced. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of a putative signal peptide sequence of 23 amino acid residues and a mature MCAF sequence of 76 amino acid residues. The amino acid sequence of MCAF showed 25-55% homology with other members of an inducible cytokine family, including macrophage inflammatory protein and some putative polypeptide mediators known as JE, LD78, RANTES and TCA-3. This suggests that MCAF is a member of family of factors involved in immune and inflammatory responses.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center