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Int J Cardiovasc Imaging. 2018 May;34(5):743-749. doi: 10.1007/s10554-017-1287-8. Epub 2017 Dec 12.

Early detection of left ventricular diastolic dysfunction using conventional and speckle tracking echocardiography in a large animal model of metabolic dysfunction.

Author information

1
Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
2
Turku PET Centre, University of Turku, Turku, Finland.
3
Department of Clinical Physiology and Nuclear Medicine, University of Turku, Turku, Finland.
4
Department of Cardiology, Franciscus Gasthuis, Rotterdam, The Netherlands.
5
Division of Biomedical Engineering, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.
6
Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. b.m.vandalen@erasmusmc.nl.
7
Department of Cardiology, Franciscus Gasthuis, Rotterdam, The Netherlands. b.m.vandalen@erasmusmc.nl.

Abstract

Left ventricular (LV) diastolic dysfunction is one of the important mechanisms responsible for symptoms in patients with heart failure. The aim of the current study was to identify parameters that may be used to detect early signs of LV diastolic dysfunction in diabetic pigs on a high fat diet, using conventional and speckle tracking echocardiography. The study population consisted of 16 healthy Göttingen minipigs and 18 minipigs with experimentally induced metabolic dysfunction. Echocardiography measurements were performed at baseline and 3-month follow-up. The ratio of peak early (E) and late filling velocity (E/A ratio) and the ratio of E and the velocity of the mitral annulus early diastolic wave (E/Em ratio) did not change significantly in both groups. Peak untwisting velocity decreased in the metabolic dysfunction group (- 30.1 ± 18.5 vs. - 23.4 ± 15.5 °/ms) but not in controls (- 38.1 ± 23.6 vs. - 42.2 ± 23.0 °/ms), being significantly different between the groups at the 3-month time point (p < 0.05). In conclusion, whereas E/A ratio and E/Em ratio did not change significantly after 3 months of metabolic dysfunction, peak untwisting velocity was significantly decreased. Hence, peak untwisting velocity may serve as an important marker to detect early changes of LV diastolic dysfunction.

KEYWORDS:

Animal model; Diabetes mellitus; Diastolic dysfunction; Echocardiography; Left ventricular untwisting; Speckle tracking echocardiography

PMID:
29234934
PMCID:
PMC5889412
DOI:
10.1007/s10554-017-1287-8
[Indexed for MEDLINE]
Free PMC Article

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