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J Neural Transm (Vienna). 2018 Feb;125(2):223-227. doi: 10.1007/s00702-017-1824-6. Epub 2017 Dec 12.

Trace lithium and mental health.

Author information

1
Department of Neuropsychiatry, Oita University Faculty of Medicine, Idaigaoka 1-1, Hasama-machi, Yufu, Oita, 879-5593, Japan. nobuy@oita-u.ac.jp.
2
Department of Neuropsychiatry, Oita University Faculty of Medicine, Idaigaoka 1-1, Hasama-machi, Yufu, Oita, 879-5593, Japan.

Abstract

Lithium therapy is generally accepted as a first-line treatment for bipolar disorder, and it is also identified as one of the best augmenting options for treatment-resistant depression. Furthermore, lithium has been investigated in association with suicide, dementia and aggressiveness. In this review, we examined articles about the effects of very small amounts of lithium in treating suicide, dementia, bipolar disorder and temperament, to assess the present state of trace lithium's effect on mental state. The results indicate that trace lithium may be effective for suicide prevention but randomized, placebo-controlled trials are required to draw a definite conclusion. Indications for using trace lithium in treating such conditions as dementia, bipolar disorder and temperament are supported by very limited evidence and such effects are yet to be determined.

KEYWORDS:

Bipolar disorder; Dementia; Lithium; Suicide; Temperament; Trace lithium

PMID:
29234900
DOI:
10.1007/s00702-017-1824-6

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