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Evid Based Complement Alternat Med. 2017;2017:7217619. doi: 10.1155/2017/7217619. Epub 2017 Oct 18.

Anxiolytic Effect of Citrus aurantium L. in Crack Users.

Author information

1
Postgraduate Program in Neuroscience Cognitive and Behavior, Federal University of Paraíba, João Pessoa, PB, Brazil.
2
Department of Nursing and Collective Health, Federal University of Paraíba, João Pessoa, PB, Brazil.
3
Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, PB, Brazil.
4
Institute of Research in Drugs and Medicines, Federal University of Paraíba, João Pessoa, PB, Brazil.

Abstract

The objective of this study was to investigate the anxiolytic effects of the essential oil (EO) of Citrus aurantium L. in patients experiencing crack withdrawal. This was developed with internal users in therapeutic communities in Paraíba, Brazil. The test population consisted of 51 volunteers, subdivided into three groups. To elicit anxiety, the Simulated Public Speaking (SPS) method was used. Physiological measures were assessed at specific phases during the experiment using appropriate equipment. Psychological measures of anxiety were assessed using the Trait-State Anxiety Inventory (IDATE) and the Analog Smoke Scale (HAS). EO was administered by nebulization. The experiment was developed in individual sessions and consolidated to four phases. The results demonstrated that the test subjects in the groups that were given the EO maintained controlled anxiety levels during SPS, when compared to the Control Group (no treatment). Subjects who used the EO also maintained levels of "discomfort" and "cognitive impairment" during SPS. It was concluded that individuals who are experiencing internal crack cocaine withdrawal present high anxiety traits and that nebulization of the EO of Citrus aurantium L. provided an acute anxiolytic effect in crack cocaine users exposed to SPS.

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