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Nat Neurosci. 2018 Jan;21(1):16-18. doi: 10.1038/s41593-017-0032-x. Epub 2017 Dec 11.

Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry.

Author information

1
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
2
23andMe, Inc., Mountain View, CA, USA.
3
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
4
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
5
Center for Deployment Psychology, Uniformed Services University, Bethesda, MD, USA.
6
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
7
Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
8
Peter Boris Centre for Addictions Research, McMaster University/St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
9
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. aap@ucsd.edu.
10
Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA. aap@ucsd.edu.

Abstract

Delay discounting (DD), the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated single-nucleotide polymorphism was rs6528024 (P = 2.40 × 10-8), which is located in an intron of the gene GPM6B. We also showed that 12% of the variance in DD was accounted for by genotype and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition and body weight.

PMID:
29230059
DOI:
10.1038/s41593-017-0032-x

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