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Trends Biotechnol. 2018 Apr;36(4):415-429. doi: 10.1016/j.tibtech.2017.11.003. Epub 2017 Dec 8.

Programming Morphogenesis through Systems and Synthetic Biology.

Author information

1
School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA; Authors contributed equally.
2
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Authors contributed equally.
3
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: patrick.cahan@jhmi.edu.
4
School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA; Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Phoenix, AZ, USA. Electronic address: mo.ebrahimkhani@asu.edu.

Abstract

Mammalian tissue development is an intricate, spatiotemporal process of self-organization that emerges from gene regulatory networks of differentiating stem cells. A major goal in stem cell biology is to gain a sufficient understanding of gene regulatory networks and cell-cell interactions to enable the reliable and robust engineering of morphogenesis. Here, we review advances in synthetic biology, single cell genomics, and multiscale modeling, which, when synthesized, provide a framework to achieve the ambitious goal of programming morphogenesis in complex tissues and organoids.

KEYWORDS:

multicellular systems; organoids; single cell genomics; stem cell self-organization; synthetic biology; systems biology

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