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Trends Immunol. 2018 Apr;39(4):261-263. doi: 10.1016/j.it.2017.11.004. Epub 2017 Dec 8.

Towards a General Theory of Immunity?

Author information

1
Microenvironment and Immunity Unit, Institut Pasteur, 75724 Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1224, 75724 Paris, France. Electronic address: gerard.eberl@pasteur.fr.
2
ImmunoConcept, Unité Mixte de Recherche 5164, Centre National de la Recherche Scientifique (CNRS) and University of Bordeaux, 33076 Bordeaux, France. Electronic address: thomas.pradeu@u-bordeaux.fr.

Abstract

Theories are indispensable to organize immunological data into coherent, explanatory, and predictive frameworks. We propose to combine different models to develop a unifying theory of immunity which situates immunology in the wider context of physiology. We believe that the immune system will be increasingly understood as a central component of a network of partner physiological systems that interconnect to maintain homeostasis.

PMID:
29229264
DOI:
10.1016/j.it.2017.11.004
[Indexed for MEDLINE]

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