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BMC Cancer. 2017 Dec 11;17(1):839. doi: 10.1186/s12885-017-3855-7.

The prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in the breast: a meta-analysis.

Author information

1
Department of Breast Surgery, Qilu Hospital, Shandong University, No.107 West Wenhua Road, Jinan, Shandong, 250012, People's Republic of China.
2
Department of Breast Surgery, Qilu Hospital, Shandong University, No.107 West Wenhua Road, Jinan, Shandong, 250012, People's Republic of China. qifengy_sdu@163.com.
3
Pathology Tissue Bank, Qilu Hospital, Shandong University, No.107 West Wenhua Road, Jinan, Shandong, 250012, People's Republic of China. qifengy_sdu@163.com.

Abstract

BACKGROUND:

Invasive micropapillary carcinoma (IMPC) of the breast is a rare variant of invasive ductal carcinoma (IDC). The prognosis of IMPC compared with that of IDC remains controversial; we conducted a meta-analysis to evaluate the prognostic difference between IMPC and IDC.

METHODS:

We searched the PubMed, Cochrane Library, and EMBASE databases for relevant studies comparing overall survival (OS), disease-specific survival (DSS), relapse-free survival (RFS), local-regional recurrence-free survival (LRRFS) or distant metastasis-free survival (DMFS) rates between IMPC and IDC. Fixed-effect and random-effect models were utilized based on the heterogeneity of the eligible studies. Heterogeneity was further evaluated by subgroup and sensitivity analyses.

RESULTS:

Fourteen studies with 1888 IMPC patients were included in the meta-analysis. The summarized odds ratio (OR) and 95% confidence interval (95% CI) was calculated to estimate the prognostic difference between IMPC and IDC. IMPC patients showed an unfavorable prognosis for RFS (OR; 2.04; 95% CI: 1.63-2.55) and LRRFS (OR: 2.82; 95% CI: 1.90-4.17) compared with IDC. However, no significant difference was observed in OS (OR: 0.93; 95% CI: 0.78-1.10), DSS (OR: 1.16; 95% CI: 0.95-1.40) and DMFS (OR: 0.95; 95% CI: 0.67-1.35) between IMPC and IDC. No obvious statistical heterogeneity was detected, except for DSS. Funnel plots and Egger's tests did not reveal publication bias, except for RFS.

CONCLUSIONS:

This analysis showed that IMPC patients have a higher rate of loco-regional recurrence than IDC patients. However, OS, DSS and DMFS were not significantly different between IMPC and IDC. These results could help clinicians select therapeutic and follow-up strategies for IMPC patients.

KEYWORDS:

Breast cancer; IMPC; Invasive micropapillary carcinoma; Meta-analysis; Prognosis; Survival

PMID:
29228910
PMCID:
PMC5725780
DOI:
10.1186/s12885-017-3855-7
[Indexed for MEDLINE]
Free PMC Article

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