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Oncotarget. 2017 Oct 9;8(57):97217-97230. doi: 10.18632/oncotarget.21743. eCollection 2017 Nov 14.

A case-control study on risk factors of breast cancer in Han Chinese women.

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Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong, 250033, China.
Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, 450008, China.
Department of Breast Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, 030013, China.
Department of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin, 130021,China.
Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, China.
Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, 256603,China.
Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, 100021, China.
Department of General Surgery, Linyi People's Hospital, Linyi, Shandong, 276003, China.
Breast Disease Center, Peking University People's Hospital, Beijing, 100044, China.
Department of General Surgery, Beijing Chaoyang Hospital, Beijing, 100043, China.
Breast Disease Center, Peking University First Hospital, Beijing, 100034, China.
Breast Center, Qingdao University Affiliated Hospital, Qingdao, Shandong, 266003, China.
Department of Breast and Thyroid Surgery, Weifang Traditional Chinese Hospital, Weifang, Shandong, 261041, China.
Department of Breast Surgery, The Second Affiliated Hospital of Qingdao Medical College, Qingdao Central Hospital, Qingdao, Shandong, 266042, China.
Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China.
Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China.
Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, 210009, China.
Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong, 255036, China.
Department of Breast Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China.
Breast Cancer Center, Shandong Cancer Hospital, Jinan, Shandong, 250117, China.


This study aimed to investigate risk factors associated with breast cancer among Han Chinese women in northern and eastern China. A matched case-control study involving 1489 patients with breast cancer and 1489 controls was conducted across 21 hospitals in 11 provinces in China, from April 2012 to April 2013. We developed a structured questionnaire to record information from face-to-face interviews with participants. Student's t-tests, Pearson's chi-square tests, and univariate and multivariate conditional logistic regression analyses were used to identify variables with significant differences between the case and control groups. Ten variables were identified (P<0.05): location, economic status, waist-to-hip ratio, menopause, family history of breast cancer, present life satisfaction, sleep satisfaction, milk products, behavior prevention scores, and awareness of breast cancer. We identified a comprehensive range of factors related to breast cancer, among which several manageable factors may contribute to breast cancer prevention. Further prospective studies concerning psychological interventions, sleep regulation, health guidance, and physical exercise are required. A screening model for high-risk populations should be put on the agenda.


Han Chinese; breast cancer; case-control study; risk factors

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no competing financial interests.

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