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Front Cell Infect Microbiol. 2017 Nov 24;7:482. doi: 10.3389/fcimb.2017.00482. eCollection 2017.

Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking.

Author information

1
Institute of Medical Microbiology, University of Zürich, Zurich, Switzerland.

Abstract

Retrograde trafficking from the endosomal system through the Golgi apparatus back to the endoplasmic reticulum is an essential pathway in eukaryotic cells, serving to maintain organelle identity and to recycle empty cargo receptors delivered by the secretory pathway. Intracellular replication of several bacterial pathogens, including Legionella pneumophila, is restricted by the retrograde trafficking pathway. L. pneumophila employs the Icm/Dot type IV secretion system (T4SS) to form the replication-permissive Legionella-containing vacuole (LCV), which is decorated with multiple components of the retrograde trafficking machinery as well as retrograde cargo receptors. The L. pneumophila effector protein RidL is secreted by the T4SS and interferes with retrograde trafficking. Here, we review recent evidence that the LCV interacts with the retrograde trafficking pathway, discuss the possible sites of action and function of RidL in the retrograde route, and put forth the hypothesis that the LCV is an acceptor compartment of retrograde transport vesicles.

KEYWORDS:

Dictyostelium discoideum; effector protein; host-pathogen interaction; pathogen vacuole; retrograde transport; retromer; sorting nexin; type IV secretion

PMID:
29226112
PMCID:
PMC5706426
DOI:
10.3389/fcimb.2017.00482
[Indexed for MEDLINE]
Free PMC Article

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