Acute basophilic leukemia associated with the t(16;21)(p11;q22)/ FUS- ERG fusion gene

Yusuke Toda; Yuya Nagai; Daiki Shimomura; Chiyuki Kishimori; Katsuyo Tsuda; Katsuhiro Fukutsuka; Masahiko Hayashida; Hitoshi Ohno

doi:10.1002/ccr3.1219

Acute basophilic leukemia associated with the t(16;21)(p11;q22)/ FUS- ERG fusion gene

Clin Case Rep. 2017 Oct 11;5(12):1938-1944. doi: 10.1002/ccr3.1219. eCollection 2017 Dec.

Authors

Yusuke Toda¹, Yuya Nagai¹, Daiki Shimomura², Chiyuki Kishimori², Katsuyo Tsuda², Katsuhiro Fukutsuka³, Masahiko Hayashida³, Hitoshi Ohno^{1

3}

Affiliations

¹ Department of Hematology Tenri Hospital Tenri Nara Japan.
² Department of Laboratory Medicine Tenri Hospital Tenri Nara Japan.
³ Tenri Institute of Medical Research Tenri Nara Japan.

Abstract

We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS-ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil-associated antigen expression, and characteristic granules under electron microscopy. The molecular link between t(16;21)/FUS-ERG and basophilic differentiation remains unclear.

Keywords: Acute basophilic leukemia; electron microscopy; metachromasia; t(16;21)(p11;q22) translocation; the FUS‐ERG fusion gene.

Publication types

Case Reports