Send to

Choose Destination
Future Virol. 2017 Sep;12(9):525-536. doi: 10.2217/fvl-2017-0021. Epub 2017 Sep 29.

Maternal nutritional status during pregnancy and infant immune response to routine childhood vaccinations.

Author information

Human Development & Health, Global Health Research Institute, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.


To systematically review the association between maternal nutritional status in pregnancy and infant immune response to childhood vaccines. We reviewed literature on maternal nutrition during pregnancy, fetal immune system and vaccines and possible relationships. Thereafter, we undertook a systematic review of the literature of maternal nutritional status and infant vaccine response, extracted relevant information, assessed quality of the nine papers identified and present findings in a narrative format. From limited evidence of average quality, intrauterine nutrition deficiency could lead to functional deficit in the infant's immune function; child vaccine response may thus be negatively affected by maternal malnutrition. Response to childhood vaccination may be associated with fetal and early life environment; evaluation of programs should take this into account.


childhood; immune response; infant; malnutrition; maternal nutrition; vaccination; vaccines

Conflict of interest statement

Financial & competing interests disclosure O Obanewa received some support from the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the NIH under Award Number R01HD080385. The literature review reported in this publication was partially supported by NICHD of the National Institutes of Health under Award Number R01HD080385. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center