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Basic Res Cardiol. 2017 Dec 9;113(1):5. doi: 10.1007/s00395-017-0663-9. Print 2018 Jan 8.

Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases.

Author information

1
Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, 453003, China.
2
Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China.
3
Central Arkansas Veterans Healthcare System and the Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
4
Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, 453003, China. wangxianwei1116@126.com.

Abstract

NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls inflammatory responses and coordinates antimicrobial host defenses by activating caspase-1 for the subsequent maturation of pro-inflammatory cytokines, IL-1β and IL-18, and induces pyroptosis. The assembly and activation of NLRP3 inflammasome are linked to the pathogenesis of several cardiovascular disease risk factors, such as hypertension and diabetes, and their major consequences-myocardial remodeling. The study of the NLRP3 inflammasome in these cardiovascular disease states may uncover important triggers and endogenous modulators of the disease, and lead to new treatment strategies. This review outlines current insights into NLRP3 inflammasome research associated with cardiovascular diseases and discusses the questions that remain in this field.

KEYWORDS:

Cardiovascular diseases; Caspase-1; IL-1β; Inflammation; NLRP3 inflammasome

PMID:
29224086
DOI:
10.1007/s00395-017-0663-9
[Indexed for MEDLINE]

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