Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration

Seyed Fazel Nabavi; Antoni Sureda; Ahmad Reza Dehpour; Samira Shirooie; Ana Sanches Silva; Kasi Pandima Devi; Touqeer Ahmed; Nafeesa Ishaq; Rabia Hashim; Eduardo Sobarzo-Sánchez; Maria Daglia; Nady Braidy; Mariateresa Volpicella; Rosa Anna Vacca; Seyed Mohammad Nabavi

doi:10.1016/j.biotechadv.2017.12.001

Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration

Biotechnol Adv. 2018 Nov 1;36(6):1768-1778. doi: 10.1016/j.biotechadv.2017.12.001. Epub 2017 Dec 6.

Authors

Affiliations

¹ Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 14359-16471, Iran.
² Research Group on Community Nutrition and Oxidative Stress (NUCOX) and CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), University of Balearic Islands, Palma de Mallorca E-07122, Balearic Islands, Spain.
³ Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
⁴ School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran.
⁵ National Institute for Agricultural and Veterinary Research (INIAV), I.P., Vairão, Vila do Conde 4480, Portugal; Center for Study in Animal Science (CECA), ICETA, University of Oporto, Oporto 4051-401, Portugal.
⁶ Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu 630 003, India.
⁷ Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan. Electronic address: touqeer.ahmed@asab.nust.edu.pk.
⁸ Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
⁹ Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago, Chile.
¹⁰ Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Pavia 27100, Italy.
¹¹ Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Australia. Electronic address: n.braidy@unsw.edu.au.
¹² Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
¹³ Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies National Council of Research, Bari, Italy.
¹⁴ Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 14359-16471, Iran. Electronic address: Nabavi208@gmail.com.

PMID: 29221764
DOI: 10.1016/j.biotechadv.2017.12.001

Abstract

In the present paper, we will discuss on the importance of autophagy in the central nervous system, and outline the relation between autophagic pathways and the pathogenesis of neurodegenerative disorders. The potential therapeutic benefits of naturally occurring phytochemicals as pharmacological modulators of autophagy will also be addressed. Our findings provide renewed insight on the molecular modes of protection by polyphenols, which is likely to be at least in part mediated not only by their potent antioxidant and anti-inflammatory effects, but also through modulation of autophagic processes to remove the aberrant protein aggregates.

Keywords: Alzheimer's disease; Autophagy; Neurodegeneration; Parkinson's disease; Polyphenols.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autophagy / drug effects*
Humans
Mice
Neurodegenerative Diseases / drug therapy*
Phytochemicals* / pharmacology
Phytochemicals* / therapeutic use
Polyphenols* / pharmacology
Polyphenols* / therapeutic use

Substances

Phytochemicals
Polyphenols