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BMC Musculoskelet Disord. 2017 Dec 8;18(1):517. doi: 10.1186/s12891-017-1884-7.

Association of body mass index with knee cartilage damage in an asymptomatic population-based study.

Author information

1
University of Toronto, Toronto, ON, Canada.
2
Arthritis Research Centre of Canada, Richmond, BC, Canada.
3
Section of Musculoskeletal Imaging, Boston University Medical Center, Boston, MA, USA.
4
Boston University School of Medicine, Boston, MA, USA.
5
Vancouver General Hospital, Vancouver, BC, Canada.
6
Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
7
Canadian HIV Trials Network, Vancouver, BC, Canada.
8
School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
9
Arthritis Research Centre of Canada, Richmond, BC, Canada. jcibere@arthritisresearch.ca.
10
Department of Medicine, University of British Columbia, Vancouver, BC, Canada. jcibere@arthritisresearch.ca.
11
Arthritis Research Canada Milan Ilich Arthritis Research Centre, 5591 No. 3 Road, Richmond, BC, V6X2C7, Canada. jcibere@arthritisresearch.ca.

Abstract

BACKGROUND:

Cartilage changes are an important early finding of osteoarthritis (OA), which can exist even before symptoms. Our objective was to determine the prevalence of knee cartilage damage on magnetic resonance imaging (MRI) in an asymptomatic population-based cross-sectional study and to evaluate the association of body mass index (BMI) with cartilage damage.

METHODS:

Subjects, aged 40-79 years, without knee pain (n = 73) were recruited as a random population sample and assessed for BMI (kg/m2), including current BMI (measured), past BMI at age 25 (self-reported) and change in BMI. Knee cartilage was scored semi-quantitatively (grades 0-4) on MRI. In primary analysis, cartilage damage was defined as ≥2 (at least moderate) and in a secondary analysis as ≥3 (severe). We also conducted a sensitivity analysis by dichotomizing current BMI as <25 vs. ≥25. Logistic regression was used to evaluate the association of each BMI variable with prevalent MRI-detected cartilage damage, adjusted for age and sex.

RESULTS:

Of 73 subjects, knee cartilage damage ≥2 and ≥3 was present in 65.4% and 28.7%, respectively. The median current BMI was 26.1, median past BMI 21.6, and median change in BMI was a gain of 2.8. For cartilage damage ≥2, current BMI had a non-statistically significant OR of 1.65 per 5 units (95% CI 0.93-2.92). For cartilage damage ≥3, current BMI showed a trend towards statistical significance with an OR of 1.70 per 5 units (95% CI 0.99-2.92). Past BMI and change in BMI were not significantly associated with cartilage damage. Current BMI ≥ 25 was statistically significantly associated with cartilage damage ≥2 (OR 3.04 (95% CI 1.10-8.42)), but not for ≥3 (OR 2.63 (95% CI 0.86-8.03)).

CONCLUSIONS:

MRI-detected knee cartilage damage was highly prevalent in this asymptomatic population-based cohort. We report a trend towards significance of BMI with cartilage damage severity. Subjects with abnormal current BMI (≥25) had a 3-fold increased odds of cartilage damage ≥2, compared to those with normal BMI. This study lends support towards the role of obesity in the pathogenesis of knee cartilage damage at an asymptomatic stage of disease.

KEYWORDS:

Asymptomatic; Cartilage; Knee; Magnetic resonance imaging; Obesity; Population-based

PMID:
29221481
PMCID:
PMC5723095
DOI:
10.1186/s12891-017-1884-7
[Indexed for MEDLINE]
Free PMC Article

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