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Cell Stem Cell. 2017 Dec 7;21(6):711-712. doi: 10.1016/j.stem.2017.11.017.

iPSC Reprogramming Is Not Just an Open and Shut Case.

Author information

1
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: peter.scacheri@case.edu.
2
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Abstract

What exactly happens to chromatin as cells undergo an identity change? In this issue of Cell Stem Cell, Li et al. (2017) and Knaupp et al. (2017) offer new insights by mapping in exquisite detail chromatin accessibility dynamics as mouse embryonic fibroblasts are reprogrammed into induced pluripotent stem cells.

PMID:
29220662
DOI:
10.1016/j.stem.2017.11.017
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