Format

Send to

Choose Destination
J Clin Endocrinol Metab. 2018 Feb 1;103(2):660-670. doi: 10.1210/jc.2017-02171.

Maternal Thyroid Function in Early Pregnancy and Neuropsychological Performance of the Child at 5 Years of Age.

Author information

1
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
2
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
3
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark.
4
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
5
Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.
6
Department of Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Abstract

Context:

Abnormal maternal thyroid function in pregnancy may impair fetal brain development, but more evidence is needed to refine and corroborate the hypothesis.

Objective:

To estimate the association between maternal thyroid function in early pregnancy and neuropsychological performance of the child at 5 years of age.

Design:

Follow-up study.

Participants:

A cohort of 1153 women and their children sampled from the Danish National Birth Cohort. Maternal thyroid-stimulating hormone (TSH) and free thyroxine (fT4) were measured in stored biobank sera from early pregnancy.

Main outcomes measures:

Child neuropsychological test results (Wechsler Intelligence Scale/Test of Everyday Attention), test of motor function (Movement Assessment Battery), and results of parent and teacher reports (Behavior Rating Inventory of Executive Function/Strengths and Difficulties Questionnaire).

Results:

Altogether 145 children (12.6%) were born to mothers with abnormal thyroid function in the early pregnancy. High maternal TSH and low fT4 were associated with lower child verbal intelligence quotient (adjusted mean difference TSH ≥ 10 mIU/L vs 0.1 to 2.49 mIU/L, -8.9 [95% confidence interval (CI), -15 to -2.4]; fT4 < 10 pmol/l vs 12.0 to 18.99 pmol/l, -13 [95% CI, -19 to -7.3]). Abnormal maternal thyroid function was also associated with adverse motor function and teacher-reported problems of executive function and behavior, and these associations were dominated by exposure to maternal hypothyroxinemia.

Conclusions:

Maternal thyroid hormone abnormalities were associated with adverse neuropsychological function of the child at 5 years of age. For intelligence, marked hypothyroidism was important, whereas for motor function and executive and behavior problems, maternal hypothyroxinemia was predominant.

PMID:
29220528
PMCID:
PMC5800834
[Available on 2019-02-01]
DOI:
10.1210/jc.2017-02171
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center