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Neth J Med. 2017 Oct;75(8):351-353.

A rare case of Waterhouse- Friderichsen syndrome during primary Varicella zoster infection.

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Department of Internal Medicine, Haaglanden Medical Centre, The Hague, the Netherlands.


Primary Varicella zoster virus infection in adults is associated with a higher risk of complications when compared with the benign disease course of primary infection during childhood. We present a rare complication of adult primary Varicella zoster in the form of acute, irreversible adrenal insufficiency due to bilateral adrenal haemorrhage, which is also known as the WaterhouseFriderichsensyndrome.

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