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J Neurosurg Pediatr. 2018 Feb;21(2):145-152. doi: 10.3171/2017.8.PEDS17264. Epub 2017 Dec 8.

Differential patterns of metastatic dissemination across medulloblastoma subgroups.

Author information

1
1Department of Paediatrics, Division of Haematology/Oncology.
2
2Pediatric Hematology and Oncology.
3
3Department of Diagnostic Imaging, Division of Neuroradiology.
4
4Neurosurgery.
5
5Pathology and Molecular Medicine, and.
6
6Radiology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
7
7Department of Paediatric Laboratory Medicine.
8
8Division of Neurosurgery, and.
9
9Programme in Neuroscience and Mental Health, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada; and Departments of.

Abstract

OBJECTIVE Metastatic dissemination is a major treatment challenge and cause of death in patients with medulloblastoma. However, the influence of molecular biology on the pattern of metastatic dissemination at diagnosis is not known. In this study, the authors sought to define the location, pattern, and imaging characteristics of medulloblastoma metastases across subgroups at diagnosis. METHODS A consecutive cohort of patients with metastatic medulloblastoma at The Hospital for Sick Children and the University Hospital Motol, who underwent up-front MRI of the craniospinal axis, was assembled and allocated to subgroups using NanoString limited gene-expression profiling. Radiological characteristics (including location, morphology, size, diffusion restriction, and contrast enhancement) were discerned through a retrospective review. RESULTS Forty metastatic medulloblastomas were identified with up-front neuroimaging of the craniospinal axis: 5 sonic hedgehog (SHH), 16 Group 3, and 19 Group 4 metastases. Significant subgroup-specific differences were observed, particularly with respect to tumor location, size, and morphology. Group 3 metastases were most frequently laminar compared with a more nodular pattern in Group 4 (14 of 16 in Group 3 vs 8 of 19 in Group 4; p = 0.0004). Laminar metastases were not observed in patients with SHH medulloblastoma. Suprasellar metastases are highly specific to Group 4 (p = 0.016). Two of the 5 SHH cases had multifocal lesions in the cerebellum, raising the possibility that these were in fact synchronous primary tumors and not true metastases. A minority of patients with Group 4 metastases harbored metastatic deposits that did not enhance on MRI after contrast administration, often in patients whose primary tumor did not enhance. CONCLUSIONS The location, morphology, and imaging characteristics of metastatic medulloblastoma differ across molecular subgroups, with implications for diagnosis and management. This suggests that the biology of leptomeningeal dissemination differs among medulloblastoma subgroups.

KEYWORDS:

MRI; SHH = sonic hedgehog; WNT = wingless; medulloblastoma; metastasis; molecular subgroups; oncology

PMID:
29219788
DOI:
10.3171/2017.8.PEDS17264
[Indexed for MEDLINE]

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