Format

Send to

Choose Destination
Pflugers Arch. 2018 May;470(5):839-849. doi: 10.1007/s00424-017-2089-5. Epub 2017 Dec 8.

The extraordinary AFD thermosensor of C. elegans.

Author information

1
Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA. mbgoodman@stanford.edu.
2
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA, 02454, USA. sengupta@brandeis.edu.

Abstract

The nematode C. elegans exhibits complex thermal experience-dependent navigation behaviors in response to environmental temperature changes of as little as 0.01°C over a > 10°C temperature range. The remarkable thermosensory abilities of this animal are mediated primarily via the single pair of AFD sensory neurons in its head. In this review, we describe the contributions of AFD to thermosensory behaviors and temperature-dependent regulation of organismal physiology. We also discuss the mechanisms that enable this neuron type to adapt to recent temperature experience and to exhibit extraordinary thermosensitivity over a wide dynamic range.

KEYWORDS:

AFD; Adaptation; C. elegans; Phosphodiesterases; Receptor guanylyl cyclases; Thermosensation

PMID:
29218454
PMCID:
PMC5945307
DOI:
10.1007/s00424-017-2089-5
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center