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Chem Commun (Camb). 2018 Jan 7;54(2):152-155. doi: 10.1039/c7cc08217g. Epub 2017 Dec 8.

Two-color vibrational imaging of glucose metabolism using stimulated Raman scattering.

Author information

1
Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA. wm2256@columbia.edu.

Abstract

A two-color vibrational imaging technique for simultaneously mapping glucose uptake and incorporation activity inside single living cells is reported. Heterogeneous patterns of glucose metabolism are directly visualized from the ratiometric two-color images for various cell types, cells undergoing epithelia-to-mesenchymal transitions and live mouse brain tissues. The two-color imaging of glucose metabolism here demonstrates the development of multi-functional vibrational probes for multicolor imaging of cellular metabolism.

PMID:
29218356
PMCID:
PMC5764084
DOI:
10.1039/c7cc08217g
[Indexed for MEDLINE]
Free PMC Article

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