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J Biomech. 2018 Jan 3;66:127-136. doi: 10.1016/j.jbiomech.2017.11.011. Epub 2017 Nov 16.

Microstructural changes associated with osteoporosis negatively affect loading-induced fluid flow around osteocytes in cortical bone.

Author information

1
Department of Biomedical Engineering, The City College of New York, New York, NY 10031, USA.
2
Department of Biomedical Engineering, The City College of New York, New York, NY 10031, USA. Electronic address: fritton@ccny.cuny.edu.

Abstract

Loading-induced interstitial fluid flow in the microporosities of bone is critical for osteocyte mechanotransduction and for the maintenance of tissue health, enhancing convective transport in the lacunar-canalicular system. In recent studies, our group has reported alterations of bone's vascular porosity and lacunar-canalicular system microarchitecture in a rat model of postmenopausal osteoporosis. In this work, poroelastic finite element analysis was used to investigate whether these microstructural changes can affect interstitial fluid flow around osteocytes. Animal-specific finite element models were developed combining micro-CT reconstructions of bone microstructure and measures of the poroelastic material properties. These models were used to quantify and compare loading-induced fluid flow in the lacunar-canalicular system of ovariectomized and sham-operated rats. A parametric analysis was also used to quantify the influence of the lacunar-canalicular permeability and vascular porosity on the fluid velocity magnitude. Results show that mechanically-induced interstitial fluid velocity can be significantly reduced in the lacunar-canalicular system of ovariectomized rats. Interestingly, the vascular porosity is shown to have a major influence on interstitial fluid flow, while the lacunar-canalicular permeability influence is limited when larger than 10-20m2. Altogether our results suggest that microstructural changes associated with the osteoporotic condition can negatively affect interstitial fluid flow around osteocytes in the lacunar-canalicular system of cortical bone. This fluid flow reduction could impair mechanosensation of the osteocytic network, possibly playing a role in the initiation and progression of age-related bone loss and postmenopausal osteoporosis.

KEYWORDS:

Bone fluid flow; Lacunar-canalicular system; Osteocyte; Osteoporosis; Poroelasticity

PMID:
29217091
PMCID:
PMC6355150
DOI:
10.1016/j.jbiomech.2017.11.011
[Indexed for MEDLINE]
Free PMC Article

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