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PLoS One. 2017 Dec 7;12(12):e0187483. doi: 10.1371/journal.pone.0187483. eCollection 2017.

Functional lung MRI for regional monitoring of patients with cystic fibrosis.

Author information

1
Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
2
Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany.
3
Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
4
Department of Experimental Physics 5, University of Würzburg, Würzburg, Germany.
5
Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

Abstract

PURPOSE:

To test quantitative functional lung MRI techniques in young adults with cystic fibrosis (CF) compared to healthy volunteers and to monitor immediate treatment effects of a single inhalation of hypertonic saline in comparison to clinical routine pulmonary function tests.

MATERIALS AND METHODS:

Sixteen clinically stable CF patients and 12 healthy volunteers prospectively underwent two functional lung MRI scans and pulmonary function tests before and 2h after a single treatment of inhaled hypertonic saline or without any treatment. MRI-derived oxygen enhanced T1 relaxation measurements, fractional ventilation, first-pass perfusion parameters and a morpho-functional CF-MRI score were acquired.

RESULTS:

Compared to healthy controls functional lung MRI detected and quantified significantly increased ventilation heterogeneity in CF patients. Regional functional lung MRI measures of ventilation and perfusion as well as the CF-MRI score and pulmonary function tests could not detect a significant treatment effect two hours after a single treatment with hypertonic saline in young adults with CF (p>0.05).

CONCLUSION:

This study shows the feasibility of functional lung MRI as a non-invasive, radiation-free tool for monitoring patients with CF.

PMID:
29216201
PMCID:
PMC5720731
DOI:
10.1371/journal.pone.0187483
[Indexed for MEDLINE]
Free PMC Article

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