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Yonsei Med J. 2018 Jan;59(1):4-12. doi: 10.3349/ymj.2018.59.1.4.

Disruption of the Gut Ecosystem by Antibiotics.

Author information

1
Department of Microbiology and Immunology, Brain Korea 21 Project for Medical Sciences, Seoul, Korea.
2
Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.
3
Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea. sangsun_yoon@yuhs.ac.

Abstract

The intestinal microbiota is a complex ecosystem consisting of various microorganisms that expands human genetic repertoire and therefore affects human health and disease. The metabolic processes and signal transduction pathways of the host and intestinal microorganisms are intimately linked, and abnormal progression of each process leads to changes in the intestinal environment. Alterations in microbial communities lead to changes in functional structures based on the metabolites produced in the gut, and these environmental changes result in various bacterial infections and chronic enteric inflammatory diseases. Here, we illustrate how antibiotics are associated with an increased risk of antibiotic-associated diseases by driving intestinal environment changes that favor the proliferation and virulence of pathogens. Understanding the pathogenesis caused by antibiotics would be a crucial key to the treatment of antibiotic-associated diseases by mitigating changes in the intestinal environment and restoring it to its original state.

KEYWORDS:

Microbiota; antibiotics; enteric pathogen; fecal microbiota transplantation (FMT); probiotics

PMID:
29214770
PMCID:
PMC5725362
DOI:
10.3349/ymj.2018.59.1.4
[Indexed for MEDLINE]
Free PMC Article

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