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Iran J Microbiol. 2017 Apr;9(2):112-118.

No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran.

Author information

1
Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
2
Mental Health Research Center, Department of Psychiatry, Iran Mental Hospital, Iran University of Medical Sciences, Tehran, Iran.
3
Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Abstract

Background and Objectives:

Viruses have been suggested as one of the risk factors for psychiatric disorders. Among infectious agents Borna disease virus (BDV) has been known as a neurotropic virus which is able to cause neurological disorders in different animals. Recently there were controversial findings about BDV association with pathogenesis of human psychotic disorders.

Materials and Methods:

Here we performed a nested reverse transcription polymerase chain reaction for detection of BDV P40 RNA in peripheral blood mononuclear cell samples of schizophrenia (SC), bipolar disorder (BD) patients and healthy controls (HCs).

Results:

Only one out of 120 (0.8 %) psychiatric patients and two samples (2.7%) in 75 HCs showed positive results. There were no significant molecular evidence of BDV infection in 120 psychotic patients (60 SC and 60 BD) and 75 matched HCs.

Conclusion:

Our findings showed no association between BDV infection and pathogenesis of these psychiatric disorders. This is an interesting issue given both the as yet un-clarified role of BDV in human mental disorders and addressing patients in the so far under-investigating Middle East era.

KEYWORDS:

Bipolar disorder; Borna disease virus; Iran; Nested RT-PCR; Schizophrenia

PMID:
29214003
PMCID:
PMC5715276

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