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Sci Transl Med. 2017 Dec 6;9(419). pii: eaam7816. doi: 10.1126/scitranslmed.aam7816.

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.

Author information

1
Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany. cstadelmann@med.uni-goettingen.de khojasteh@em.mpg.de msimons@gwdg.de.
2
Department of Neuropathology, University of Göttingen Medical Center, 37075 Göttingen, Germany.
3
Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.
4
Department of Neuro- and Sensory Physiology, University of Göttingen Medical Center, 37073 Göttingen, Germany.
5
Max Planck Institute for Biophysical Chemistry, 37073 Göttingen, Germany.
6
Department of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.
7
Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.
8
Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.
9
Bioanalytical Mass Spectrometry Group, Department of Clinical Chemistry, University of Göttingen Medical Center, Robert Koch Straße 40, 37075 Göttingen, Germany.
10
Molecular and Translational Neuroscience, Department of Neurology, Medical Faculty, Ulm University, 89081 Ulm, Germany.
11
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
12
Department of Neuropathology, University of Göttingen Medical Center, 37075 Göttingen, Germany. cstadelmann@med.uni-goettingen.de khojasteh@em.mpg.de msimons@gwdg.de.
13
Institute of Neuronal Cell Biology, Technical University of Munich, 80805 Munich, Germany.
14
German Center for Neurodegenerative Diseases (DZNE), 6250 Munich, Germany.

Abstract

Investigations into brain function and disease depend on the precise classification of neural cell types. Cells of the oligodendrocyte lineage differ greatly in their morphology, but accurate identification has thus far only been possible for oligodendrocyte progenitor cells and mature oligodendrocytes in humans. We find that breast carcinoma amplified sequence 1 (BCAS1) expression identifies an oligodendroglial subpopulation in the mouse and human brain. These cells are newly formed, myelinating oligodendrocytes that segregate from oligodendrocyte progenitor cells and mature oligodendrocytes and mark regions of active myelin formation in development and in the adult. We find that BCAS1+ oligodendrocytes are restricted to the fetal and early postnatal human white matter but remain in the cortical gray matter until old age. BCAS1+ oligodendrocytes are reformed after experimental demyelination and found in a proportion of chronic white matter lesions of patients with multiple sclerosis (MS) even in a subset of patients with advanced disease. Our work identifies a means to map ongoing myelin formation in health and disease and presents a potential cellular target for remyelination therapies in MS.

PMID:
29212715
DOI:
10.1126/scitranslmed.aam7816
[Indexed for MEDLINE]

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