Format

Send to

Choose Destination
Oncotarget. 2017 Oct 16;8(55):95005-95022. doi: 10.18632/oncotarget.21887. eCollection 2017 Nov 7.

Regulation of DNA replication-coupled histone gene expression.

Mei Q1, Huang J1, Chen W1,2, Tang J1, Xu C1, Yu Q1, Cheng Y1, Ma L1,2, Yu X1,2, Li S1,2.

Author information

1
Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, Wuhan, Hubei 430062, China.
2
Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, Wuhan, Hubei 430062, China.

Abstract

The expression of core histone genes is cell cycle regulated. Large amounts of histones are required to restore duplicated chromatin during S phase when DNA replication occurs. Over-expression and excess accumulation of histones outside S phase are toxic to cells and therefore cells need to restrict histone expression to S phase. Misregulation of histone gene expression leads to defects in cell cycle progression, genome stability, DNA damage response and transcriptional regulation. Here, we discussed the factors involved in histone gene regulation as well as the underlying mechanism. Understanding the histone regulation mechanism will shed lights on elucidating the side effects of certain cancer chemotherapeutic drugs and developing potential biomarkers for tumor cells.

KEYWORDS:

DNA replication; cell cycle; histone gene transcription

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that there are no conflicts of interest.

Publication type

Publication type

Supplemental Content

Full text links

Icon for Impact Journals, LLC Icon for PubMed Central
Loading ...
Support Center