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Exp Dermatol. 2018 Aug;27(8):824-826. doi: 10.1111/exd.13478. Epub 2018 Jan 9.

Effect of tannic acid on skin barrier function.

Author information

1
Department of R&D Center, Ikeda Mohando Co., Ltd, Toyama, Japan.

Abstract

In this study, we investigated how tannic acid (TA) protects the skin from inflammation caused by external irritation. The effects of TA were evaluated using a mouse 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced skin inflammation model and a reconstructed human epidermal model. We then used Lucifer Yellow for visual confirmation of TA's suppression effect at the stratum corneum (SC) surface. TA treatment of the skin prevented Lucifer Yellow from permeating the skin. This result suggests that TA acts as a barrier against external stimulants such as TPA and artificial sweat on the SC surface.

KEYWORDS:

artificial sweat; damaged skin; stratum corneum

PMID:
29211928
DOI:
10.1111/exd.13478
[Indexed for MEDLINE]

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