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Anal Chem. 2018 Jan 2;90(1):961-967. doi: 10.1021/acs.analchem.7b04015. Epub 2017 Dec 19.

Gold Nanoparticles Decorated Hematite Photoelectrode for Sensitive and Selective Photoelectrochemical Aptasensing of Lysozyme.

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School of Chemistry and Molecular Engineering, East China Normal University , 500 Dongchuan Road, Shanghai 200241, China.


Photoelectrochemical aptasensor (PECAS) is a new and promising detection platform with both high sensitivity and good selectivity. Exploration of new photoelectrode materials and establishment of effective charge transfer channel between photoelectrode and aptamer are the main challenges in this field. In this work, an efficient PECAS based on Au nanoparticles (NPs) decorated Fe2O3 nanorod photoelectrode is rationally designed, fabricated, and exhibited excellent sensitivity and selectivity for detection of lysozyme (Lys) with an ultralow detection limit of 3 pM and wide detection range from 10 pM to 100 nM. The Au NPs not only act as anchor to establish an efficient charge transfer channel between the photoelectrode and the aptamer, but also help to enhance the PEC performance through adjusting the carrier density of Fe2O3. The rationally designed photoelectrode opens up a distinctive avenue for promoting the PECAS to be a versatile analysis method.

[Indexed for MEDLINE]

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